Protein Details: Potassium voltage-gated channel subfamily KQT member 2
Protein ID
ICDB_Pro_1739
Protein Name
Potassium voltage-gated channel subfamily KQT member 2
Gene Name
KCNQ2; KQT2
Organism
Mus musculus (Mouse)
Length
759 amino acids
AlphaFoldDB
AF-Q9Z351-F1-model_v4.pdb
Function
Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current; a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore; it is important in the regulation of neuronal excitability. KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium; in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity; increasing Na(+) and Cs(+) permeation relative to K(+) permeation (By similarity)
Sequence
PDB Structures
Ligand Binding
Binding Site
681
Disease
Location
Exclusively expressed in the brain. Expressed in every neuron-containing regions of the central nervous system examined; such as the cerebellum; cerebral cortex; occipital pole; substantia nigra; amygdala; caudate nucleus; hippocampus and thalamus. Also detected in the cochlea.
DOI ID
10.1523/jneurosci.22-18-07991.2002; 10.1126/science.1112014; 10.1046/j.1471-4159.2000.0750028.x; 10.1074/mcp.t500041-mcp200; 10.1016/j.cell.2010.12.001; 10.1074/jbc.m116.758029
RefSeq
NP_001006675.1; NP_001289817.1; NP_034741.2